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Intraoperative Ureter Visualization using ASP5354 with NIR-F Imaging (Abdominal and Pelvic Surgery) - Clinical Trial

What is the Purpose of this Study?

We are doing this study to find out if an experimental drug called ASP5354 (the study drug) is a safe and effective option that can help surgeons see patients' ureters better during surgeries.

What is the Condition Being Studied?

Abdominal/Pelvic Surgery

Who Can Participate in the Study?

Adults ages 18+ who are scheduled to have an abdominal or pelvic surgery at Duke.

For more information about this study, contact the study team at felecia.walton@duke.edu.

Age Group
Adults

What is Involved?

If you choose to join this study, you will get a random assignment to either:

  • Get a single dose of the study drug during your surgery; OR
  • Get a placebo (inactive substance with no drug in it) during your surgery

You will have a 5-in-6 chance of getting the study drug and a 1-in-6 chance of getting the placebo.

Study Details

Full Title
A Phase 3, Multicenter, Prospective, Randomized, Open-label Study for Intraoperative Ureter(s) Visualization When Using ASP5354 with Near-infrared Fluorescence (NIR-F) Imaging in Adult Participants Undergoing Minimally Invasive and Open Abdominopelvic Surgeries
Principal Investigator
Colorectal Surgeon
Protocol Number
IRB: PRO00116263
NCT: NCT05754333
Phase
Phase III
ClinicalTrials.gov
Enrollment Status
Open for Enrollment Soon