GOG-3068 HIPEC (Hyperthermic Ovarian Cancer Treatment) - Clinical Trial

What is the Purpose of this Study?

We are doing this study to find out if giving heated chemotherapy into the belly, a procedure known as heated intraperitoneal chemotherapy (HIPEC), can improve treatment results for patients with ovarian cancer.

What is the Condition Being Studied?

Stage III and IV Ovarian Cancer

Who Can Participate in the Study?

Adults ages 18+ who:

Are diagnosed with stages III-IV ovarian cancer
Have not received previous treatment for ovarian cancer with the exception of the first 3-4 cycles of platinum-based neoadjuvant chemotherapy

For more information about who can join this study, please contact the study team at 919-684-3780.

Age Group

Adults

What is Involved?

If you choose to join this study, you will get a random assignment (like a coin flip) to 1 of 2 groups:

One group of participants will receive neoadjuvant chemotherapy with paclitaxel/docetaxel/Nab-paclitaxel and carboplatin. They will then undergo surgery, and then receive HIPEC at the time of surgery.
The other group will receive neoadjuvant chemotherapy with paclitaxel/docetaxel/Nab-paclitaxel and carboplatin. They will then undergo surgery followed by standard postoperative chemotherapy with paclitaxel/docetaxel/Nab-paclitaxel and carboplatin.

Participants in both groups will then receive maintenance therapy with niraparib for up to 3 years.

Study Details

Full Title

A Phase III Randomized Trial of Hyperthermic Intraperitoneal Chemotherapy (HIPEC) with Cisplatin versus no HIPEC at the Time of Interval Cytoreductive Surgery followed by Niraparib Maintenance in Patients with Newly Diagnosed Stage III and IV Ovarian, Primary Peritoneal, and Fallopian Tube Cancer (Hyperthermic Ovarian Treatment Trial)

Principal Investigator