Lupus

Make an Appointment
You have been seen by a Duke provider for rheumatology and immunology care within the last three years or you need to reschedule an appointment.

or call

919-684-0761

Lupus is a complex autoimmune disease that can cause inflammation in many different parts of the body. Specialists in Duke Health's rheumatology program are renowned for their research, approach to care, and treatment of lupus. We use innovative approaches to manage your lupus.

Find a Lupus Doctor
Matching Results
Filter Results
Filter by:
Use My Current Location
Located Near You
Loading Results
Showing of Doctors
Load More View All
×

About Lupus

Lupus is a chronic autoimmune disease in which the immune system attacks healthy tissues in the body. Lupus can present with a variety of symptoms including swollen joints, skin rashes, kidney inflammation, fatigue, fever, and pain. Lupus is best diagnosed and managed by a specialist.  

Our experienced rheumatologists have the skills and tools to make an accurate diagnosis and outline a comprehensive treatment plan. We work with you and other specialists across Duke to help you manage the effects of lupus on your body’s multiple systems and organs. 

Our Locations

Duke Health offers locations throughout the Triangle. Find one near you.

Lupus Treatments

We strive to help you manage the full spectrum of lupus, allowing you to participate in the activities you enjoy. Your treatments options may include:

Hydroxychloroquine (Plaquenil)

Decreases the risk of lupus flares, progressive renal disease, and death from lupus. It is often the first medication we use to treat the disease. Hydroxychloroquine also helps relieve lupus symptoms such as skin rashes, joint pain, and mouth sores.  

Prednisone

This steroid reduces swelling and inflammation. Because prednisone can cause side effects, we try to use it at the lowest dose and for the shortest amount of time while we find alternative immune medications and therapies to treat lupus and decrease the long-term use of steroids.

Immune-Suppressing Drugs

Drugs that lower the body’s overactive immune response can help treat inflammatory lupus symptoms. Depending on the specific medication, these immune-suppressing drugs can help relieve symptoms such as arthritis; rash; and kidney, lung, and heart inflammation.

  • Methotrexate
  • Azathioprine (Imuran)
  • Mycophenolate mofetil (Cellcept or Myfortic)
  • Cyclophosphamide (Cytoxan) 
  • Belimumab (Benlysta)
  • Anifrolumab (Saphenlo)
  • Voclosporin (Lupkynis)
  • Rituxan (Rituximab) 
     

Physical Therapy

Aquatic exercise, biking, walking, and stretching can help relieve the pain and fatigue associated with lupus. Physical activity can decrease the long-term cardiovascular risk associated with lupus. 

Psychological Counseling

Chronic pain, depression, anxiety, and sleep problems are common among patients with lupus. Psychological counseling, cognitive behavioral, or acceptance and commitment therapy can be a valuable way to help manage chronic symptoms. We collaborate with therapists, psychologists, and psychiatrists to develop the best plan for your care.

New Patient Appointment

Tests for Lupus

Lupus is diagnosed by using a combination of laboratory tests, medical history, and a comprehensive physical exam. Your evaluation -- which may require multiple visits -- may include: 

Blood and Urine Tests

Your doctor will order blood and urine tests to check blood counts, identify kidney and liver function, and search for lupus antibodies and markers of lupus activity. People with lupus often have abnormal blood counts, elevated autoantibodies, and low complement levels.

Biopsy

Depending on your lupus symptoms and lab testing, you may be referred to a nephrologist or dermatologist to take a small sample of kidney tissue or skin to confirm your diagnosis.  

Other Tests

You may undergo radiology, ultrasound, or breathing tests to help your doctor better understand and manage your disease. Imaging tests may include X-rays, CT scans, echocardiograms, or pulmonary function tests. 

High-Performing Hospital for Rheumatology in the U.S.

Where you receive your care matters. Duke University Hospital is proud of our team and the exceptional care they provide. They are why our rheumatology program is rated as high-performing among the nation's top hospitals, according to US News & World Report for 2024–2025.

Expert Lupus Care

Comprehensive, Coordinated Care
We have a robust network of subspecialists who play a key role in managing the many aspects of systemic lupus erythematosus (SLE). We collaborate with dermatology, nephrology, hematology, pulmonology, cardiology, obstetrics/gynecology, psychiatry, and neurology to provide a comprehensive, patient-centered approach to your care. This multidisciplinary approach ensures that every aspect of your lupus is addressed with specialized expertise, allowing us to deliver tailored, holistic care to our patients.

Specialized Care Before and During Pregnancy
We are one of the few centers in the nation to offer care focused on women with lupus who are pregnant or plan to become pregnant. We work closely with Duke’s high-risk maternal fetal medicine specialists to safely coordinate medications during pregnancy. By providing individualized treatment plans and collaborating with maternal fetal medicine specialists, we strive to ensure optimal health outcomes for both women with lupus and their babies.

Active Research Program
Our research program includes the Duke Lupus Registry, which is a detailed clinical registry about lupus and is the basis for several clinical and translational research projects. The goal of the registry is to understand the impact of lupus, gain new knowledge about lupus, and establish best practices for caring for people living with lupus. All Duke Lupus Clinic patients are welcome to participate in the Duke Lupus Registry. You may be eligible to participate in other lupus-specific clinical trials, or observational registries that test new therapies for lupus.

Patient Resources

This page was medically reviewed on 10/30/2024 by