Lymphoma

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Duke’s lymphoma specialists treat people with all types of lymphoma -- a group of cancers of the lymphatic system, which is part of your body's immune system. The different types of lymphoma, include:

Hodgkin lymphoma (HL)
Non-Hodgkin lymphoma (NHL), of which there are 30 different types
Chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL)
Waldenstrom's macroglobulinemia/lymphoplasmacytic lymphoma (LPL)
Cutaneous lymphoma, which affects the skin

Because these lymphomas act and are treated differently, it is important to receive an accurate diagnosis to ensure you receive the best possible care for your type of lymphoma. Our lymphoma experts create a personalized treatment plan that uses the most effective therapies. This may include options to participate in clinical trials.

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Tests for Lymphoma

Biopsy

A biopsy removes a small amount of tissue for examination under a microscope by a pathologist. There are different types of biopsies, including lymph nodes, bone marrow, skin, or other organs that may have lymphoma. Some biopsies are performed with needles in the clinic or done by radiology; others require surgery. If the specific type of lymphoma is not clear, you may be advised to repeat a biopsy to obtain a larger sample, since your type of lymphoma will determine your individualized treatment plan.

MRI, PET, and CT Scans

These imaging tests help your doctor diagnose lymphomas and recommend the best treatment plan.

Genetic Tests

Unlike other forms of genetic testing, which look for conditions that may run in your family, this type of testing examines the genetic makeup of your lymphoma. This helps your doctor better understand the biology behind your condition. This can help us predict how lymphoma may act over time and, in some cases, choose the best possible therapies. Some genetic studies are only available at Duke.

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Duke Health offers locations throughout the Triangle. Find one near you.

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Treatments for Lymphoma

Active Surveillance

Active surveillance may be recommended if you are not having symptoms and your oncologist finds no indications for treatment.

Radiation Therapy

Our radiation oncologists design an individualized plan to target the tumor to kill or slow the growth of cancer cells.

Targeted Therapy

Targeted therapies block the growth of cancer cells or interfere with processes that help cancer cells survive. Many targeted therapies are taken orally; how often they are taken can vary. Monoclonal antibody therapy is a targeted therapy that is administered through an IV, by itself or in combination with other targeted therapies or chemotherapy.

Chemotherapy

Systemic chemotherapy is administered via oral medication, by infusion into a vein, or by injection.

Stem Cell or Bone Marrow Transplant

A stem cell or bone marrow transplant replaces lymphoma cells with healthy blood cells.

CAR T-Cell Therapy for Advanced Non-Hodgkin Lymphoma

We are an authorized treatment center for two FDA-approved CAR T-cell therapies (brand names: Yescarta and Kymriah) for the treatment of certain advanced non-Hodgkin lymphomas. People with advanced non-Hodgkin lymphoma who have failed at least two lines of systemic treatment may be candidates for this one-time treatment.

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Why Choose Duke

Largest Lymphoma Center in North Carolina
We treat 1,000 people with blood cancer each year -- more than any other facility in North Carolina -- and we have a team dedicated to working with people who have lymphoma. In addition, as a National Cancer Institute-designated Comprehensive Cancer Center, we are recognized as meeting rigorous standards for laboratory, clinical, and population-based research, and for focusing our scientific efforts on developing new and better ways to prevent, diagnose, and treat cancer. We are also part of the National Comprehensive Cancer Network, an alliance of the nation’s leading cancer centers dedicated to improving patient care.

The Duke Cancer Institute
The Duke Cancer Institute brings together the extensive resources of Duke University, Duke Health, and the Duke Comprehensive Cancer Center. We are committed to making innovative discoveries, developing new ways to prevent, diagnose, and treat cancer, and delivering those therapies in a patient- and family-centric way.

A Team of Lymphoma Specialists
Our team -- medical, radiation, and surgical oncologists; dermatologists; palliative care specialists; psychologists; infectious disease doctors; radiologists; specially trained nurses; nutritionists; and social workers -- meet regularly to discuss your care, collect opinions, and offer coordinated treatment recommendations and follow-up.

Clinical Trial Access
You may be eligible to participate in clinical trials of new targeted therapies and ways to minimize common cancer-related symptoms before they become widely available at other hospitals.

Advanced Therapies Available
We are one of the few centers authorized to administer a new class of FDA-approved treatments called CAR T-cell therapy (brand names: Yescarta and Kymriah). Our researchers are also exploring differences among lymphomas that will lead to improved therapies.

Support for You and Your Family
Our comprehensive support services are here for you throughout your treatment. We help minimize the side effects of treatment and offer support to help you cope with the emotional and psychological effects of diagnosis and treatment. You may also benefit from our services that focus on nutrition, guided imagery, anxiety control, and meditation. Our cancer survivorship and chronic care clinic pulls together a range of resources specially designed to help you after your treatment ends or while you are undergoing active surveillance for your chronic condition. View all of our cancer support groups on our event calendar.

Best Cancer Hospital in North Carolina

Where you receive your cancer care is important. Duke University Hospital is proud of our team and the exceptional care they provide. They are why our cancer program is nationally ranked, and the highest-ranked program in North Carolina, according to U.S. News & World Report for 2024–2025.

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This page was medically reviewed on 11/21/2019