Talal I. Mousallem, MD
Allergy & Immunology Specialist, Pediatric Allergy and Immunology Specialist
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About Me
I am an allergist and immunologist who cares for children and adults. I manage patients with primary immunodeficiency and different allergic diseases. This includes managing patients with recurrent infections, allergic rhinitis, asthma, food allergy, drug allergy, stinging insect hypersensitivity, urticaria/ angioedema, and allergic skin disease. I also see patients with abnormal severe combined immunodeficiency newborn screen results.
- Associate Professor of Pediatrics, Pediatrics, Allergy and Immunology 2021
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Ratings and Reviews
The ratings and reviews are based on patient responses to the overall provider rating question from the survey. The question reads: “Using any number from 0 to 10, where 0 is the worst provider possible and 10 is the best provider possible, what number would you use to rate this provider?” Responses are converted to a 5-point rating system and applied consistently to all providers. Learn more about our survey process. Patients who see some types of providers receive a different version of the patient satisfaction survey. Those results are not available on DukeHealth.org.
Training and Education
Clinical Focus and Research
My area of research interest is immunogenetics. To date, there are more than 350 different primary immunodeficiencies described in the scientific literature. In some cases, the molecular defect remains unknown. The focus of my research work is investigating the genetic cause of primary immunodeficiency diseases using next-generation sequencing technology in patients where the molecular defect (genetic cause) remains unknown.
- Primary Immune Deficiency Treatment Consortium awarded by University of California - San Francisco 2014 - 2025
- Cresoe-Ortiz, Samantha, Geoffrey Hall, Rachel L. Randell, Monica G. Lawrence, Aarat Patel, Christina Peroutka, Qingping Yao, and Talal Mousallem. “Yao syndrome in a child with C2 deficiency.” J Allergy Clin Immunol Pract 12, no. 11 (November 2024): 3159–62. https://doi.org/10.1016/j.jaip.2024.08.018.
- Hicks, Elizabeth Daly, Geoffrey Hall, Michael S. Hershfield, Teresa K. Tarrant, Pawan Bali, John W. Sleasman, Rebecca H. Buckley, and Talal Mousallem. “Treatment with Elapegademase Restores Immunity in Infants with Adenosine Deaminase Deficient Severe Combined Immunodeficiency.” J Clin Immunol 44, no. 5 (April 27, 2024): 107. https://doi.org/10.1007/s10875-024-01710-z.
- Donkó, Ágnes, Svetlana O. Sharapova, Juraj Kabat, Sundar Ganesan, Fabian H. Hauck, Jenna R. E. Bergerson, Louis Marois, et al. “Clinical and functional spectrum of RAC2-related immunodeficiency.” Blood 143, no. 15 (April 11, 2024): 1476–87. https://doi.org/10.1182/blood.2023022098.
- Mousallem, Talal. “Oral allergy syndrome.” In Encyclopedia of Medical Immunology, edited by I. Mackay and N. Rose, 534–37. Springer Science and Business Media, 2014.
- Mousallem, Talal, and rose Boustany. “Sphingolipid disorders and the neuronal ceroid lipofuscinoses.” In Emery and Rimoin’s Principles and Practice of Medical Genetics, edited by D. L. Rimoin, J. M. Connor, R. E. Pyeritz, B. R. Korf, and B. R. editors, 2449–85. Philadelphia Churchill Livingstone Elsevier, 2006.
- Mousallem, Talal, Jialong Yang, Thomas J. Urban, Hongxia Wang, Roberta E. Parrott, Joseph L. Roberts, Rebecca H. Buckley, Xiaoping Zhong, and David B. Goldstein. “Whole-Exome Sequencing Reveals IKBKB As a Cause of Combined Immunodeficiency.” In Journal of Allergy and Clinical Immunology, 133:AB399–AB399. Elsevier BV, 2014. https://doi.org/10.1016/j.jaci.2013.12.1053.
- Mousallem, Talal, Thomas J. Urban, Joseph L. Roberts, Roberta E. Parrott, David B. Goldstein, and Rebecca H. Buckley. “Next Generation Sequencing May Be More Efficient and Economical Than Targeted Gene Testing in Patients with Primary Immune Deficiency (PID).” In Journal of Allergy and Clinical Immunology, 131:AB52–AB52. Elsevier BV, 2013. https://doi.org/10.1016/j.jaci.2012.12.870.
Insurance Accepted
Duke Health contracts with most major health insurance carriers and transplant networks, including the ones listed below.
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Aetna
- Aetna Choice POS, Aetna Choice POS II
- Aetna Elect Choice HMO, Aetna Open Access Elect Choice
- Aetna Health Network Only, Aetna Health Network Option
- Aetna HMO
- Aetna Limited Benefit Insurance PPO
- Aetna Managed Choice POS
- Aetna Medicare Assure Plan (HMO D-SNP)
- Aetna Medicare Eagle Plan (PPO)
- Aetna Medicare Essential Plan (PPO)
- Aetna Medicare Value Plan (HMO)
- Aetna Open Access HMO, Open Access Aetna Select, Aetna Open Access Managed Choice
- Aetna Open Choice PPO
- Aetna PCP Coordinated POS Plan
- Aetna Quality Point of Service (QPOS)
- Aetna Select HMO
- Aetna Traditional Choice
- Aetna Voluntary Indemnity Group Plan
- Aetna Whole Health – Duke WakeMed WKCC
- Aetna/CVS Health
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Ambetter
- Ambetter of North Carolina
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Blue Cross Blue Shield of NC
- Blue Advantage
- Blue Medicare (HMO, PPO)*
- Blue Options (123, PPO, HSA)
- Blue Select
- NC State Employees Health Plan
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*Duke HomeCare and Hospice does not participate in the plan.
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Cigna
- Cigna Behavioral Health (*Limited eligibility)
- Cigna Choice Plus
- Cigna Connect Individual Family Plan
- Cigna Open Access
- Cigna Open Access Plus
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*Please call Cigna Behavioral Heath to see if the provider is participating in your plan.
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Duke Group Plans
- Duke Basic
- Duke Select
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Experience Health
- Experience Health Medicare Advantage (HMO) Plan
- Gateway Health Alliance
- Healthgram
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Humana
- Humana Choice (PPO)
- Humana Choice - Medicare Advantage (PPO)
- Humana ChoiceCare - Medicare Advantage (PPO)
- Humana Gold Choice - Medicare Advantage (PFFS)
- Humana Gold Plus - Medicare Advantage (HMO)
- Humana Medicare Advantage Group Plan - NC State Retirees
- MedCost
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Medicare
- First Medicare Direct
- Medicare Part A
- Medicare Part B
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NC Medicaid
- AmeriHealth Caritas North Carolina
- Carolina Complete Health
- Healthy Blue
- NC Medicaid Direct
- WellCare of North Carolina
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TRICARE
- TRICARE Prime
- TRICARE Prime Remote
- TRICARE Select
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United Healthcare
- AARP Medicare Advantage Plan 2 (HMO-POS)
- AARP Medicare Complete (HMO, PPO)*
- AARP Medicare Complete Essential (HMO)*
- All Savers Alternate Funding
- All Savers Fully Insured
- United Healthcare (HMO, PPO, POS)**
- United Healthcare Charter/Charter Balance/Charter Plus
- United Healthcare Choice/Choice Plus
- United Healthcare Core/Core Essential
- United Healthcare Navigate/Navigate Plus/Navigate Balanced
- United Healthcare Option PPO
- United Healthcare Passport Connect Choice/Choice Plus
- United Healthcare Passport Connect Options PPO
- United Healthcare Select/Select Plus
- United Healthcare Shared Services - Harvard Pilgrim/UHC Options PPO Network
- United Medical Resources (UMR)
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*Duke HomeCare and Hospice and mental health providers do not participate with the plan.
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**Duke Health does not participate in UHC plans on the Health Insurance Marketplace.
Before scheduling your appointment, we strongly recommend you contact your insurance company to verify that the Duke Health location or provider you plan to visit is included in your network. Your insurance company will also be able to inform you of any co-payments, co–insurances, or deductibles that will be your responsibility. If you proceed in scheduling an appointment and your health insurance benefits do not participate with Duke, your out of pocket liability may be higher. We will contact you regarding your coverage and patient liability. If you are uninsured, learn more about our financial assistance policy.
External Relationships
- Chiesi USA
- Grifols
- Horizon Therapeutics (formerly Horizon Pharmaceuticals) puurchased in 2023 by Amgen
- adma biologics