Senthil Selvaraj, MD, MS, MA
Advanced Heart Failure Specialist, Cardiologist
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About Me
I am a cardiologist specializing in advanced heart failure and heart transplants. I see patients across the entire spectrum of heart failure, including early to late stages. In more advanced cases, I discuss the role of therapies, such as devices and heart transplants. My goal is to ensure that each patient receives optimal treatment for their condition. I provide a personalized approach to care and seek to understand the patient's unique story and journey. I enjoy answering questions about different treatment approaches and finding the right one for the patient. My passion for heart failure stems from excitement and appreciation for a growing number of effective treatment strategies in the field, and I look forward to discussing these with my patients. I am active in research, including clinical trials, and would be happy to discuss any opportunities to participate. In my free time, I enjoy getting to know the area, traveling, and spending time with my family.
LGBTQ+ Identified or Ally
- Assistant Professor of Medicine, Medicine, Cardiology 2022
- Member of Duke Molecular Physiology Institute, Duke Molecular Physiology Institute 2022
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Ratings and Reviews
The ratings and reviews are based on patient responses to the overall provider rating question from the survey. The question reads: “Using any number from 0 to 10, where 0 is the worst provider possible and 10 is the best provider possible, what number would you use to rate this provider?” Responses are converted to a 5-point rating system and applied consistently to all providers. Learn more about our survey process. Patients who see some types of providers receive a different version of the patient satisfaction survey. Those results are not available on DukeHealth.org.
Training and Education
In the News
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Clinical Focus and Research
My research focuses on novel treatment strategies for patients with heart failure. I lead or am involved in several trials for new therapies. I have a particular interest in metabolic treatments that may change the "fuel" or substrates that the heart uses. These studies range from smaller studies looking to improve exercise capacity to larger studies investigating whether treatment can reduce hospitalizations or improve quality of life.
- Selvaraj, Senthil, Antoneta Karaj, Julio A. Chirinos, Nicole Denney, Gabby Grosso, Melissa Fernando, Kishon Chambers, et al. “Crossover Trial of Exogenous Ketones on Cardiometabolic Endpoints in Heart Failure With Preserved Ejection Fraction.” JACC Heart Fail, March 29, 2025. https://doi.org/10.1016/j.jchf.2025.03.002.
- Selvaraj, Senthil, Lydia Coulter Kwee, Elizabeth J. Thompson, Mengshu He, Christoph P. Hornik, Adam D. Devore, Chetan B. Patel, et al. “Metabolic and Pharmacokinetic Profiling of a Ketone Ester by Background SGLT2 Inhibitor Therapy in HFrEF.” JACC Basic Transl Sci 10, no. 3 (March 2025): 290–303. https://doi.org/10.1016/j.jacbts.2024.10.014.
- Ostrominski, John W., Petar M. Seferović, and Senthil Selvaraj. “Metabolic dysfunction: An important driver of incident heart failure with preserved and reduced ejection fraction.” Eur J Heart Fail 27, no. 3 (March 2025): 508–11. https://doi.org/10.1002/ejhf.3507.
- Selvaraj, S Senthil, B. Claggett, C. Quarta, B. Yu, R. Inciardi, J. Buxbaum, T. H. Mosley, et al. “Age dependency of cardiovascular outcomes with the amyloidogenic p142I transthyretin variant among black individuals.” In EUROPEAN JOURNAL OF HEART FAILURE, 25:86–87, 2023.
- Vidula, Mahesh, Senthil Selvaraj, Chaitanya Rojulpote, Abhijit Bhattaru, Mary Hansbury, Erin Schubert, Caitlin Clancy, et al. “Relationship of beta-hydroxybutyrate levels and ketosis duration with diagnostic FDG-PET studies performed for the evaluation of active cardiac sarcoidosis.” In JOURNAL OF NUCLEAR MEDICINE, Vol. 64, 2023.
- Selvaraj, Senthil, Kenneth Margulies, Svati Shah, Supritha Dugyala, Erin Schubert, Daniel Pryma, Daniel Kelly, and Paco Bravo. “Endogenous versus Exogenous Ketosis to Suppress Myocardial Glucose Uptake on FDG-PET: KEETO-CROSS.” In JOURNAL OF NUCLEAR MEDICINE, Vol. 62, 2021.
Insurance Accepted
Duke Health contracts with most major health insurance carriers and transplant networks, including the ones listed below.
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Aetna
- Aetna Choice POS, Aetna Choice POS II
- Aetna Elect Choice HMO, Aetna Open Access Elect Choice
- Aetna Health Network Only, Aetna Health Network Option
- Aetna HMO
- Aetna Limited Benefit Insurance PPO
- Aetna Managed Choice POS
- Aetna Medicare Assure Plan (HMO D-SNP)
- Aetna Medicare Eagle Plan (PPO)
- Aetna Medicare Essential Plan (PPO)
- Aetna Medicare Value Plan (HMO)
- Aetna Open Access HMO, Open Access Aetna Select, Aetna Open Access Managed Choice
- Aetna Open Choice PPO
- Aetna PCP Coordinated POS Plan
- Aetna Quality Point of Service (QPOS)
- Aetna Select HMO
- Aetna Traditional Choice
- Aetna Voluntary Indemnity Group Plan
- Aetna Whole Health – Duke WakeMed WKCC
- Aetna/CVS Health
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Ambetter
- Ambetter of North Carolina
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Blue Cross Blue Shield of NC
- Blue Advantage
- Blue Medicare (HMO, PPO)*
- Blue Options (123, PPO, HSA)
- Blue Select
- NC State Employees Health Plan
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*Duke HomeCare and Hospice does not participate in the plan.
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Cigna
- Cigna Behavioral Health (*Limited eligibility)
- Cigna Choice Plus
- Cigna Connect Individual Family Plan
- Cigna Open Access
- Cigna Open Access Plus
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*Please call Cigna Behavioral Heath to see if the provider is participating in your plan.
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Duke Group Plans
- Duke Basic
- Duke Select
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Experience Health
- Experience Health Medicare Advantage (HMO) Plan
- Gateway Health Alliance
- Healthgram
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Humana
- Humana Choice (PPO)
- Humana Choice - Medicare Advantage (PPO)
- Humana ChoiceCare - Medicare Advantage (PPO)
- Humana Gold Choice - Medicare Advantage (PFFS)
- Humana Gold Plus - Medicare Advantage (HMO)
- Humana Medicare Advantage Group Plan - NC State Retirees
- MedCost
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Medicare
- First Medicare Direct
- Medicare Part A
- Medicare Part B
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NC Medicaid
- AmeriHealth Caritas North Carolina
- Carolina Complete Health
- Healthy Blue
- NC Medicaid Direct
- WellCare of North Carolina
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TRICARE
- TRICARE Prime
- TRICARE Prime Remote
- TRICARE Select
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United Healthcare
- AARP Medicare Advantage Plan 2 (HMO-POS)
- AARP Medicare Complete (HMO, PPO)*
- AARP Medicare Complete Essential (HMO)*
- All Savers Alternate Funding
- All Savers Fully Insured
- United Healthcare (HMO, PPO, POS)**
- United Healthcare Charter/Charter Balance/Charter Plus
- United Healthcare Choice/Choice Plus
- United Healthcare Core/Core Essential
- United Healthcare Navigate/Navigate Plus/Navigate Balanced
- United Healthcare Option PPO
- United Healthcare Passport Connect Choice/Choice Plus
- United Healthcare Passport Connect Options PPO
- United Healthcare Select/Select Plus
- United Healthcare Shared Services - Harvard Pilgrim/UHC Options PPO Network
- United Medical Resources (UMR)
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*Duke HomeCare and Hospice and mental health providers do not participate with the plan.
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**Duke Health does not participate in UHC plans on the Health Insurance Marketplace.
Before scheduling your appointment, we strongly recommend you contact your insurance company to verify that the Duke Health location or provider you plan to visit is included in your network. Your insurance company will also be able to inform you of any co-payments, co–insurances, or deductibles that will be your responsibility. If you proceed in scheduling an appointment and your health insurance benefits do not participate with Duke, your out of pocket liability may be higher. We will contact you regarding your coverage and patient liability. If you are uninsured, learn more about our financial assistance policy.
External Relationships
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- Hospital of the University of Pennsylvania