Dwight D. Koeberl, MD, PhD
Medical Genetics Specialist, Pediatric Medical Genetics Specialist
My Locations
About Me
My practice includes caring for children and adults with inherited conditions, such as inherited disorders of metabolism, genetic syndromes, mitochondrial disorders, inherited causes of growth failure or developmental delay, and conditions detected by newborn screening. My clinic works with the Pediatric Biochemical Genetics Laboratory to diagnose these conditions. We provide treatment for inherited disorders of metabolism. I work closely with the geneticists, neurologists, pediatricians, internists, and other providers at Duke University Medical Center to provide comprehensive care for my patients. My research has been aimed at developing new treatments for inherited conditions, focusing on glycogen storage diseases, like Pompe disease and von Gierke disease. We have developed gene therapy for these conditions and are in the process of starting clinical trials to test safety and benefits.
- Professor of Pediatrics, Pediatrics, Medical Genetics 2015
- Professor of Cell Biology, Cell Biology 2022
- Professor in Molecular Genetics and Microbiology, Molecular Genetics and Microbiology 2015
Call for an Appointment
Ratings and Reviews
The ratings and reviews are based on patient responses to the overall provider rating question from the survey. The question reads: “Using any number from 0 to 10, where 0 is the worst provider possible and 10 is the best provider possible, what number would you use to rate this provider?” Responses are converted to a 5-point rating system and applied consistently to all providers. Learn more about our survey process. Patients who see some types of providers receive a different version of the patient satisfaction survey. Those results are not available on DukeHealth.org.
Training and Education
Clinical Focus and Research
- Han, Sang-Oh, Songtao Li, Angela McCall, Benjamin Arnson, Jeffrey I. Everitt, Haoyue Zhang, Sarah P. Young, Mai K. ElMallah, and Dwight D. Koeberl. “Comparisons of Infant and Adult Mice Reveal Age Effects for Liver Depot Gene Therapy in Pompe Disease.” Mol Ther Methods Clin Dev 17 (June 12, 2020): 133–42. https://doi.org/10.1016/j.omtm.2019.11.020.
- Kang, Hye-Ri, Monika Gjorgjieva, Stephanie N. Smith, Elizabeth D. Brooks, Zelin Chen, Shawn M. Burgess, Randy J. Chandler, et al. “Pathogenesis of Hepatic Tumors following Gene Therapy in Murine and Canine Models of Glycogen Storage Disease.” Mol Ther Methods Clin Dev 15 (December 13, 2019): 383–91. https://doi.org/10.1016/j.omtm.2019.10.016.
- Kang, Hye-Ri, Lauren Waskowicz, Andrea M. Seifts, Dustin J. Landau, Sarah P. Young, and Dwight D. Koeberl. “Bezafibrate Enhances AAV Vector-Mediated Genome Editing in Glycogen Storage Disease Type Ia.” Mol Ther Methods Clin Dev 13 (June 14, 2019): 265–73. https://doi.org/10.1016/j.omtm.2019.02.002.
- Koeberl, D. D. “Mucolipidoses.” In Garner and Klintworth’s Pathobiology of Ocular Disease Part B, Third Edition, 941–52, 2007.
- Koeberl, D. D., S. Young, D. Millington, and G. K. Klintworth. “Disorders of amino acid metabolism.” In Garner and Klintworth’s Pathobiology of Ocular Disease Part B, Third Edition, 953–82, 2007.
- Demo, E., D. D. Koeberl, and P. S. Kishnani. “Lysosomal storage and transport disorders.” In Garner and Klintworth’s Pathobiology of Ocular Disease Part B, Third Edition, 857–68, 2007.
- Harb, Jerry F., Shih-hsin Kan, Nancy D. Dalton, Alejandra Padilla, Chloe Christensen, Allisandra K. Rha, Perla Andrade-Heckman, et al. “Exploring Pompe disease: Insights into the natural history of novel knock-in murine model.” In Molecular Genetics and Metabolism, 141:107873–107873. Elsevier BV, 2024. https://doi.org/10.1016/j.ymgme.2023.107873.
- Kan, Shih-hsin, Jerry F. Harb, Songtao Li, Nancy D. Dalton, Alejandra Padilla, Chloe Christensen, Allisandra Rha, et al. “Improvement of hypertrophic cardiomyopathy in knock-in murine model with neonatal gene therapy.” In Molecular Genetics and Metabolism, 141:107908–107908. Elsevier BV, 2024. https://doi.org/10.1016/j.ymgme.2023.107908.
- Smith, Edward C., Sam Hopkins, Laura E. Case, Martin K. Childers, Sang-Oh Han, Tracy G. Spears, Christoph P. Hornik, Deeksha Bali, Priya S. Kishnani, and Dwight D. Koeberl. “Phase 1 Study of Gene Therapy in Late-Onset Pompe Disease: Initial 104-Week Experience.” In MOLECULAR THERAPY, 30:563–64, 2022.
Insurance Accepted
Duke Health contracts with most major health insurance carriers and transplant networks, including the ones listed below.
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Aetna
- Aetna Choice POS, Aetna Choice POS II
- Aetna Elect Choice HMO, Aetna Open Access Elect Choice
- Aetna Health Network Only, Aetna Health Network Option
- Aetna HMO
- Aetna Limited Benefit Insurance PPO
- Aetna Managed Choice POS
- Aetna Medicare Assure Plan (HMO D-SNP)
- Aetna Medicare Eagle Plan (PPO)
- Aetna Medicare Essential Plan (PPO)
- Aetna Medicare Value Plan (HMO)
- Aetna Open Access HMO, Open Access Aetna Select, Aetna Open Access Managed Choice
- Aetna Open Choice PPO
- Aetna PCP Coordinated POS Plan
- Aetna Quality Point of Service (QPOS)
- Aetna Select HMO
- Aetna Traditional Choice
- Aetna Voluntary Indemnity Group Plan
- Aetna Whole Health – Duke WakeMed WKCC
- Aetna/CVS Health
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Ambetter
- Ambetter of North Carolina
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Blue Cross Blue Shield of NC
- Blue Advantage
- Blue Medicare (HMO, PPO)*
- Blue Options (123, PPO, HSA)
- Blue Select
- NC State Employees Health Plan
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*Duke HomeCare and Hospice does not participate in the plan.
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Cigna
- Cigna Behavioral Health (*Limited eligibility)
- Cigna Choice Plus
- Cigna Connect Individual Family Plan
- Cigna Open Access
- Cigna Open Access Plus
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*Please call Cigna Behavioral Heath to see if the provider is participating in your plan.
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Duke Group Plans
- Duke Basic
- Duke Select
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Experience Health
- Experience Health Medicare Advantage (HMO) Plan
- Gateway Health Alliance
- Healthgram
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Humana
- Humana Choice (PPO)
- Humana Choice - Medicare Advantage (PPO)
- Humana ChoiceCare - Medicare Advantage (PPO)
- Humana Gold Choice - Medicare Advantage (PFFS)
- Humana Gold Plus - Medicare Advantage (HMO)
- Humana Medicare Advantage Group Plan - NC State Retirees
- MedCost
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Medicare
- First Medicare Direct
- Medicare Part A
- Medicare Part B
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NC Medicaid
- AmeriHealth Caritas North Carolina
- Carolina Complete Health
- Healthy Blue
- NC Medicaid Direct
- WellCare of North Carolina
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TRICARE
- TRICARE Prime
- TRICARE Prime Remote
- TRICARE Select
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United Healthcare
- AARP Medicare Advantage Plan 2 (HMO-POS)
- AARP Medicare Complete (HMO, PPO)*
- AARP Medicare Complete Essential (HMO)*
- All Savers Alternate Funding
- All Savers Fully Insured
- United Healthcare (HMO, PPO, POS)**
- United Healthcare Charter/Charter Balance/Charter Plus
- United Healthcare Choice/Choice Plus
- United Healthcare Core/Core Essential
- United Healthcare Navigate/Navigate Plus/Navigate Balanced
- United Healthcare Option PPO
- United Healthcare Passport Connect Choice/Choice Plus
- United Healthcare Passport Connect Options PPO
- United Healthcare Select/Select Plus
- United Healthcare Shared Services - Harvard Pilgrim/UHC Options PPO Network
- United Medical Resources (UMR)
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*Duke HomeCare and Hospice and mental health providers do not participate with the plan.
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**Duke Health does not participate in UHC plans on the Health Insurance Marketplace.
Before scheduling your appointment, we strongly recommend you contact your insurance company to verify that the Duke Health location or provider you plan to visit is included in your network. Your insurance company will also be able to inform you of any co-payments, co–insurances, or deductibles that will be your responsibility. If you proceed in scheduling an appointment and your health insurance benefits do not participate with Duke, your out of pocket liability may be higher. We will contact you regarding your coverage and patient liability. If you are uninsured, learn more about our financial assistance policy.
External Relationships
- Acacia Therapeutics Inc.
- AskBio
- Bayer
- Moderna Therapeutics, Inc.
- Pfizer Inc.
- Takeda Pharmaceutical Co. Ltd.