Christopher L. Holley, MD, PhD
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Our ability to support very sick patients has increased dramatically over the past decade, and it is a true privilege to be part of that team here at Duke.
– Christopher L. Holley, MD, PhD

Christopher L. Holley, MD, PhD

Advanced Heart Failure Specialist, Cardiologist

Duke Health Provider question
Areas of Expertise
Heart Failure
Heart Transplant Evaluation
VAD Evaluation Care
Multi-Organ Transplant
Where I See Patients
Duke University Hospital - Durham, NC
Location Details
Board Certified
American Board of Internal Med, Cardiovascular Disease
American Board of Internal Med, Advanced Heart Failure and Transplant Cardiology
Our ability to support very sick patients has increased dramatically over the past decade, and it is a true privilege to be part of that team here at Duke.
– Christopher L. Holley, MD, PhD

My Locations

About Me

As a cardiologist and advanced heart failure specialist, I take care of many patients who are awaiting (or have already received) heart transplantation, as well as patients who are being supported by implanted mechanical devices known as VADs (ventricular assist devices). Our ability to support very sick patients has increased dramatically over the past decade, and it is a true privilege to be part of that team here at Duke.

Current Appointments and Affiliations
  • Associate Professor of Medicine, Medicine, Cardiology 2021
  • Assistant Research Professor of Molecular Genetics and Microbiology, Molecular Genetics and Microbiology 2017
Languages I Speak
English

Areas of Expertise

Training and Education

Board Certification
American Board of Internal Med, Cardiovascular Disease
American Board of Internal Med, Advanced Heart Failure and Transplant Cardiology
Fellowship
Cardiovascular Disease, Washington University/Barnes-Jewish Hospital (Missouri), 2006-2011
Residency
Internal Medicine, Washington University/Barnes-Jewish Hospital (Missouri), 2004-2006
Education
MD, Duke University School of Medicine, 2004
PhD, Duke University, 2004

Clinical Focus and Research

My Research Interests

My research laboratory studies how oxidative stress affects the heart and vascular system. In most types of cardiovascular disease, there is an increase in oxidative stress that leads to cell damage and dysfunction. By studying how cardiovascular diseases create oxidative stress and how the body tries to limit that damage, we hope to develop new therapies that can improve the lives of heart and vascular patients.

Publications and Grants
  • Vader, J. M., C. L. Holley, and M. W. Rich. “Chronic heart failure.” In , 215–36, 2015. https://doi.org/10.1007/978-1-4939-1929-1_13.
  • Bales, C. W., J. L. Locher, and E. Saltzman. “Handbook of clinical nutrition and aging, third edition,” 1–442, 2015. https://doi.org/10.1007/978-1-4939-1929-1.
  • Holley, C. L. “Evaluation of Acute Chest Pain.” In , edited by P. Cuculich and A. Kates. Philadelphia, PA: Lippencott Williams & Wilkins, 2014.

Insurance Accepted

Duke Health contracts with most major health insurance carriers and transplant networks, including the ones listed below.

    • Aetna Choice POS, Aetna Choice POS II
    • Aetna Elect Choice HMO, Aetna Open Access Elect Choice
    • Aetna Health Network Only, Aetna Health Network Option
    • Aetna HMO
    • Aetna Limited Benefit Insurance PPO
    • Aetna Managed Choice POS
    • Aetna Medicare Assure Plan (HMO D-SNP)
    • Aetna Medicare Eagle Plan (PPO)
    • Aetna Medicare Essential Plan (PPO)
    • Aetna Medicare Value Plan (HMO)
    • Aetna Open Access HMO, Open Access Aetna Select, Aetna Open Access Managed Choice
    • Aetna Open Choice PPO
    • Aetna PCP Coordinated POS Plan
    • Aetna Quality Point of Service (QPOS)
    • Aetna Select HMO
    • Aetna Traditional Choice
    • Aetna Voluntary Indemnity Group Plan
    • Aetna Whole Health – Duke WakeMed WKCC
    • Aetna/CVS Health
    • Ambetter of North Carolina
    • Blue Advantage
    • Blue Medicare (HMO, PPO)*
    • Blue Options (123, PPO, HSA)
    • Blue Select
    • NC State Employees Health Plan

    • *Duke HomeCare and Hospice does not participate in the plan.

    • Cigna Behavioral Health (*Limited eligibility)
    • Cigna Choice Plus
    • Cigna Connect Individual Family Plan
    • Cigna Open Access
    • Cigna Open Access Plus

    • *Please call Cigna Behavioral Heath to see if the provider is participating in your plan.

    • Duke Basic
    • Duke Select
    • Experience Health Medicare Advantage (HMO) Plan
  • Gateway Health Alliance
  • Healthgram
    • Humana Choice (PPO)
    • Humana Choice - Medicare Advantage (PPO)
    • Humana ChoiceCare - Medicare Advantage (PPO)
    • Humana Gold Choice - Medicare Advantage (PFFS)
    • Humana Gold Plus - Medicare Advantage (HMO)
    • Humana Medicare Advantage Group Plan - NC State Retirees
  • MedCost
    • First Medicare Direct
    • Medicare Part A
    • Medicare Part B
    • AmeriHealth Caritas North Carolina
    • Carolina Complete Health
    • Healthy Blue
    • NC Medicaid Direct
    • WellCare of North Carolina
    • TRICARE Prime
    • TRICARE Prime Remote
    • TRICARE Select
    • AARP Medicare Advantage Plan 2 (HMO-POS)
    • AARP Medicare Complete (HMO, PPO)*
    • AARP Medicare Complete Essential (HMO)*
    • All Savers Alternate Funding
    • All Savers Fully Insured
    • United Healthcare (HMO, PPO, POS)**
    • United Healthcare Charter/Charter Balance/Charter Plus
    • United Healthcare Choice/Choice Plus
    • United Healthcare Core/Core Essential
    • United Healthcare Navigate/Navigate Plus/Navigate Balanced
    • United Healthcare Option PPO
    • United Healthcare Passport Connect Choice/Choice Plus
    • United Healthcare Passport Connect Options PPO
    • United Healthcare Select/Select Plus
    • United Healthcare Shared Services - Harvard Pilgrim/UHC Options PPO Network
    • United Medical Resources (UMR)

    • *Duke HomeCare and Hospice and mental health providers do not participate with the plan.

    • **Duke Health does not participate in UHC plans on the Health Insurance Marketplace.

Before scheduling your appointment, we strongly recommend you contact your insurance company to verify that the Duke Health location or provider you plan to visit is included in your network. Your insurance company will also be able to inform you of any co-payments, co–insurances, or deductibles that will be your responsibility. If you proceed in scheduling an appointment and your health insurance benefits do not participate with Duke, your out of pocket liability may be higher. We will contact you regarding your coverage and patient liability. If you are uninsured, learn more about our financial assistance policy.

External Relationships

This faculty member (or a member of their immediate family) has reported outside activities with the companies or institutions listed below. This information has been reported to the health system leadership and, when appropriate, management plans are in place to address potential conflicts of interest.
  • Novo Nordisk
  • OneFul Health
  • snoPanTher