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About Me
Liver disease is a disease that’s stigmatized. Many people are embarrassed to say they have liver disease, and that’s because liver disease is associated with alcoholism or drug abuse. But most people have liver disease that’s not related to those issues at all. People who smoke cigarettes get bad diseases, and we try not to stigmatize them. So it’s very difficult to be a patient with liver disease. They often feel isolated. But what has struck me about all of my patients is that they are very supportive of each other, and their families tend to be very supportive of them. They weather their condition with great grace, and they’re very grateful for the help we can provide. One of the things that distinguishes the gastroenterology division at Duke is that we have a very balanced faculty. Many programs specialize in one thing or another. Duke really covers the spectrum of gastrointestinal diseases. We have the breadth of general gastroenterologists, but we also have the sub-subspecialties.
- Florence McAlister Distinguished Professor of Medicine, Medicine, Gastroenterology 2005
- Professor of Medicine, Medicine, Gastroenterology 2004
- Affiliate of the Duke Regeneration Center, Duke Regeneration Center 2021
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Ratings and Reviews
The ratings and reviews are based on patient responses to the overall provider rating question from the survey. The question reads: “Using any number from 0 to 10, where 0 is the worst provider possible and 10 is the best provider possible, what number would you use to rate this provider?” Responses are converted to a 5-point rating system and applied consistently to all providers. Learn more about our survey process. Patients who see some types of providers receive a different version of the patient satisfaction survey. Those results are not available on DukeHealth.org.
Training and Education
In the News
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Clinical Focus and Research
I have devoted my career to studying how to improve recovery from liver injury. This is important for patients with all types of liver disease, because the two main causes of death from liver disease, cirrhosis and liver cancer, can develop when repair of liver damage is defective. My basic research laboratory showed that certain inflammatory factors help the liver to regenerate. In addition, we discovered that processes that form the liver during fetal development become reactivated in injured adult livers and help them to regenerate. These discoveries are leading to novel ways to diagnose and treat patients with liver disease so that cirrhosis and liver cancer can be prevented. I lead a team of scientists and doctors who are extending this work to patients. We have active clinical research programs in nonalcoholic fatty liver disease, sclerosing cholangitis and cirrhosis. In addition, I take care of patients with all kinds of liver disease.
- Genomic Imprinting in the Development of NAFLD awarded by National Institutes of Health 2024 - 2028
- Omenetti, A., Y. Popov, Y. Jung, S. S. Choi, R. P. Witek, L. Yang, K. D. Brown, D. Schuppan, and A. M. Diehl. “The hedgehog pathway regulates remodelling responses to biliary obstruction in rats.” Gut 57, no. 9 (September 2008): 1275–82. https://doi.org/10.1136/gut.2008.148619.
- Yang, Liu, Youngmi Jung, Alessia Omenetti, Rafal P. Witek, Steve Choi, Hendrika M. Vandongen, Jiawen Huang, Gianfranco D. Alpini, and Anna Mae Diehl. “Fate-mapping evidence that hepatic stellate cells are epithelial progenitors in adult mouse livers.” Stem Cells 26, no. 8 (August 2008): 2104–13. https://doi.org/10.1634/stemcells.2008-0115.
- Ouyang, Xiaosen, Pietro Cirillo, Yuri Sautin, Shannon McCall, James L. Bruchette, Anna Mae Diehl, Richard J. Johnson, and Manal F. Abdelmalek. “Fructose consumption as a risk factor for non-alcoholic fatty liver disease.” J Hepatol 48, no. 6 (June 2008): 993–99. https://doi.org/10.1016/j.jhep.2008.02.011.
- Ochoa, B., A. M. Diehl, and S. C. Stainbrook. “Tissues & organs.” In Encyclopedia of Biological Chemistry: Third Edition, 5:437–43, 2021. https://doi.org/10.1016/B978-0-12-819460-7.00268-1.
- Machado, M. V., and A. M. Diehl. “Developmental morphogens and adult liver repair.” In The Liver: Biology and Pathobiology, 539–49, 2020. https://doi.org/10.1002/9781119436812.ch43.
- Choi, S. S., and A. M. Diehl. “Alcoholic liver disease.” In Handbook of Liver Disease, 109–20, 2018. https://doi.org/10.1016/B978-0-323-47874-8.00008-0.
- Du, Kuo, Raquel Maeso-Díaz, Seh Hoon Oh, Ergang Wang, Tianyi Chen, Christopher Pan, Kun Xiang, et al. “Targeting YAP-mediated HSC death susceptibility and senescence for treatment of liver fibrosis.” In Hepatology, 77:1998–2015, 2023. https://doi.org/10.1097/HEP.0000000000000326.
- Chen, Tianyi, George Dalton, Seh-Hoon Oh, Raquel Maeso-Diaz, Kuo Du, Rachel A. Meyers, Cynthia Guy, et al. “Hepatocyte Smoothened Activity Controls Susceptibility to Insulin Resistance and Nonalcoholic Fatty Liver Disease.” In Cell Mol Gastroenterol Hepatol, 15:949–70, 2023. https://doi.org/10.1016/j.jcmgh.2022.12.008.
- Maeso-Díaz, Raquel, George D. Dalton, Sehhoon Oh, Kuo Du, Linda Tang, Tianyi Chen, Rajesh K. Dutta, Jessica H. Hartman, Joel N. Meyer, and Anna Mae Diehl. “Aging reduces liver resiliency by dysregulating Hedgehog signaling.” In Aging Cell, 21:e13530, 2022. https://doi.org/10.1111/acel.13530.
Insurance Accepted
Duke Health contracts with most major health insurance carriers and transplant networks, including the ones listed below.
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Aetna
- Aetna Choice POS, Aetna Choice POS II
- Aetna Elect Choice HMO, Aetna Open Access Elect Choice
- Aetna Health Network Only, Aetna Health Network Option
- Aetna HMO
- Aetna Limited Benefit Insurance PPO
- Aetna Managed Choice POS
- Aetna Medicare Assure Plan (HMO D-SNP)
- Aetna Medicare Eagle Plan (PPO)
- Aetna Medicare Essential Plan (PPO)
- Aetna Medicare Value Plan (HMO)
- Aetna Open Access HMO, Open Access Aetna Select, Aetna Open Access Managed Choice
- Aetna Open Choice PPO
- Aetna PCP Coordinated POS Plan
- Aetna Quality Point of Service (QPOS)
- Aetna Select HMO
- Aetna Traditional Choice
- Aetna Voluntary Indemnity Group Plan
- Aetna Whole Health – Duke WakeMed WKCC
- Aetna/CVS Health
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Ambetter
- Ambetter of North Carolina
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Blue Cross Blue Shield of NC
- Blue Advantage
- Blue Medicare (HMO, PPO)*
- Blue Options (123, PPO, HSA)
- Blue Select
- NC State Employees Health Plan
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*Duke HomeCare and Hospice does not participate in the plan.
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Cigna
- Cigna Behavioral Health (*Limited eligibility)
- Cigna Choice Plus
- Cigna Connect Individual Family Plan
- Cigna Open Access
- Cigna Open Access Plus
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*Please call Cigna Behavioral Heath to see if the provider is participating in your plan.
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Duke Group Plans
- Duke Basic
- Duke Select
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Experience Health
- Experience Health Medicare Advantage (HMO) Plan
- Gateway Health Alliance
- Healthgram
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Humana
- Humana Choice (PPO)
- Humana Choice - Medicare Advantage (PPO)
- Humana ChoiceCare - Medicare Advantage (PPO)
- Humana Gold Choice - Medicare Advantage (PFFS)
- Humana Gold Plus - Medicare Advantage (HMO)
- Humana Medicare Advantage Group Plan - NC State Retirees
- MedCost
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Medicare
- First Medicare Direct
- Medicare Part A
- Medicare Part B
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NC Medicaid
- AmeriHealth Caritas North Carolina
- Carolina Complete Health
- Healthy Blue
- NC Medicaid Direct
- WellCare of North Carolina
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TRICARE
- TRICARE Prime
- TRICARE Prime Remote
- TRICARE Select
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United Healthcare
- AARP Medicare Advantage Plan 2 (HMO-POS)
- AARP Medicare Complete (HMO, PPO)*
- AARP Medicare Complete Essential (HMO)*
- All Savers Alternate Funding
- All Savers Fully Insured
- United Healthcare (HMO, PPO, POS)**
- United Healthcare Charter/Charter Balance/Charter Plus
- United Healthcare Choice/Choice Plus
- United Healthcare Core/Core Essential
- United Healthcare Navigate/Navigate Plus/Navigate Balanced
- United Healthcare Option PPO
- United Healthcare Passport Connect Choice/Choice Plus
- United Healthcare Passport Connect Options PPO
- United Healthcare Select/Select Plus
- United Healthcare Shared Services - Harvard Pilgrim/UHC Options PPO Network
- United Medical Resources (UMR)
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*Duke HomeCare and Hospice and mental health providers do not participate with the plan.
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**Duke Health does not participate in UHC plans on the Health Insurance Marketplace.
Before scheduling your appointment, we strongly recommend you contact your insurance company to verify that the Duke Health location or provider you plan to visit is included in your network. Your insurance company will also be able to inform you of any co-payments, co–insurances, or deductibles that will be your responsibility. If you proceed in scheduling an appointment and your health insurance benefits do not participate with Duke, your out of pocket liability may be higher. We will contact you regarding your coverage and patient liability. If you are uninsured, learn more about our financial assistance policy.
External Relationships
- American Association for Study of Liver Diseases and American Gastroenterological Association
- American Association for the Study of Liver Disease (AASLD)
- American Association for the Study of Liver Disease (AASLD)
- American Society of Nephrology
- Boehringer Ingleheim
- FALK Symposium on Liver Disease - Invited Speaker
- Keystone Symposia
- LA CATS (Lousiana CTSA)
- NCI
- NIAAA
- Northern Ohio Alcohol Research Center
- Saint Louis University
- University of California Los Angeles
- University of Louisville
- University of Massachusetts Worster
- University of Michigan
- University of Pittsburgh