NDPH biomarker study (New Daily Persistent Headache) - Clinical Trial

What is the Purpose of this Study?

We are doing this study to learn more about the rare diagnosis of New Daily Persistent Headache (NDPH). We want to get more information about why some children and young people develop this condition and how it is different from traditional headaches, like migraines. This knowledge can help us to begin developing possible treatments for NDPH.

What is the Condition Being Studied?

New Daily Persistent Headache (NDPH)

Who Can Participate in the Study?

Adolescents ages 12-18 who:

  • Are diagnosed with or suspected to have NDPH
  • Have no history of Raynaud's syndrome
  • Have no history of concussion or neurosurgery

Healthy adolescents with no medical issues or adolescents with a history of normal migraine headaches can also join the study as control participants and give a blood sample.

For more information, please contact the study team at brittany.nave@duke.edu.

Age Group
Children

What is Involved?

If you choose to have your child join this study, they will:

  • Visit our clinic 2 times
  • Have an exam
  • Have blood draws
  • Answer questionnaires
  • Keep a diary of their headache symptoms for 4 months

The visits to our clinic for this study will be about 4 months apart. Their study participation will end after the second visit. The study doctor might suggest some headache remedies to try during their time in the study.

Study Details

Full Title
New Daily Persistent Headache (NDPH): Biomarker study and therapy in children and adolescents.
Principal Investigator
Protocol Number
IRB: PRO00113907
NCT: NCT06018025
Phase
Phase N/A
ClinicalTrials.gov
Enrollment Status
Open for Enrollment