CROWN Study (Breast Cancer) - Clinical Trial

What is the Purpose of this Study?

We are doing this study to better understand how breast cancer treatment can affect the heart. In particular, we want to know if treatment with near complete estrogen deprivation (NCED) therapy has an impact on heart function.

What is the Condition Being Studied?

Risk of Heart Injury in Women Receiving Therapy for Breast Cancer

Who Can Participate in the Study?

Women ages 55 or younger who:

Are premenopausal when they receive their breast cancer diagnosis
Have Stage 1-to-3 breast cancer
Have recently started or plan to start breast cancer treatment therapy

For more information about who can be in this study, please contact the study team at BreastCl@dm.duke.edu.

Age Group

Adults

What is Involved?

If you choose to join this study, you will:

Have 3 heart stress tests over the course of 2 years
Have a cardiac MRI at the beginning of the study, at the 1 year mark, and at the end of the study
Get a CT scan at the beginning of the study and 2 years later at the end
Have an EKG/ECG (measures the electrical signal from the heart) 3 times
Have up to 6 blood draws throughout the study