D2C7 + Anti-CD40 for Malignant Glioma - Clinical Trial

What is the Purpose of this Study?

We are doing this study to see if an experimental combination of drugs (D2C7-IT and 2141-V11) is a safe treatment for brain tumors.

What is the Condition Being Studied?

Brain Tumors

Who Can Participate in the Study?

Adults 18 years of age and older who:

Are diagnosed with Grade III or IV malignant glioma that has progressed or recurred
Do not take a high dose of a steroid medicine called Decadron or dexamethasone
Are not taking any types of medicines that affect your immune system

For more information about this study, please contact the team at 919-684-5301.

Age Group

Adults

What is Involved?

If you choose to join this study, you will:

Have the study drugs (D2C7-IT and 2141-V11) put into the area around your tumor
Stay in the hospital for approximately 4 days
Have physical exams
Give blood samples
Have MRI scans

You will have regular follow-up visits after you leave the hospital. You will have a return clinic visit 2 weeks, 4 weeks, and 8 weeks after your hospital stay and then every 8 weeks for at least one year.

Study Details

Full Title

A Phase 1 Trial of D2C7-IT in Combination with an Fc-engineered Anti-CD40 Monoclonal Antibody (2141-V11) Administered Intratumorally via Convection-Enhanced Delivery for Adult Patients with Recurrent Malignant Glioma

Principal Investigator