S2200: Advanced Papillary Renal Cell Carcinoma (PAPMET2) - Clinical Trial
What is the Purpose of this Study?
We are doing this study to compare two treatment options for PRCC. We want to know if adding an experimental drug called atezolimumab (the study drug) to the typical drug used in PRCC treatment, cabozantinib, can improve outcomes or extend survival time.
What is the Condition Being Studied?
Papillary Renal Cell Carcinoma (PRCC) that has spread to other parts of the body
Who Can Participate in the Study?
Adults ages 18+ who:
- Are diagnosed with metastatic PRCC, either type 1 or type 2
- Do not require specific treatment for active brain metastases at the time of joining the study and won't require treatment until the first cycle of the study regimen is done
- Have never used cabozantinib
- Have not been treated with PD-1/PD-L1 checkpoint inhibitors for any reason within the past 6 months
- Have not have received more than one prior systemic therapy for advanced or metastatic renal cell carcinoma with the exception of another VEGF inhibitor FDA-approved for advanced RCC
For more information about who can join this study, please contact the study team at nick.jeffries@duke.edu.
Age Group
Adults
What is Involved?
If you choose to join this study, you will be randomly assigned (like a coin flip) to 1 of 2 groups:
- One group will get the cabozantinib. You will take cabozantinib tablets every day. Each three-week period is called a "cycle."
- The other group will cabozantinib in combination with the study drug. You will take cabozantinib tablets every day. Each three-week period is called a cycle. The study drug is given intravenously (IV) through a vein in your arm on the first day of each cycle.
Study Details
Full Title
S2200: A Phase II Randomized Trial of Cabozantinib (NSC #761968) with or Without Atezolizumab (NSC #783608) in Patients with Advanced Papillary Renal Cell Carcinoma (PAPMET2)
Principal Investigator
Medical Oncologist
Protocol Number
IRB:
PRO00113295
NCT:
NCT05411081
Phase
Phase
II
ClinicalTrials.gov
View on ClinicalTrials.gov
Enrollment Status
Open for Enrollment