Ph I/II of GOS in acute GVHD (Stem Cell Transplantation) - Clinical Trial

Email to Participate

What is the Purpose of this Study?

We are doing this study to see if taking a prebiotic (dietary supplement) can reduce the risk of acute graft-versus-host disease (a common complication) in people who receive an allogeneic stem cell transplant. This study is important because prebiotics are a common and safe dietary supplement, and there is a need for a safe and effective way to reduce graft-versus-host disease after transplant.

What is the Condition Being Studied?

Allogeneic (Donor) Stem Cell Transplant

Who Can Participate in the Study?

Adults ages 18-80 who:

Are scheduled to get an allogeneic stem cell transplant for any type of illness
Are able to read and write in English
Are not pregnant or nursing
Do not have any disease or condition affecting their digestive tract
Are not using any prebiotic, probiotic, or antibiotic

For more information about who can join this study, please contact the study team at andrea.pires@duke.edu or 919-668-4978.

Age Group

Adults

What is Involved?

If you choose to join the study, you will:

Be randomly asssigned (like a coin flip) to receive the prebiotic (food additive that affects gut bacteria) or a placebo (food additive that does not affect gut bacteria)
Give stool samples
Have your skin swabbed
Have blood draws
Fill out questionnaires
Have Cardiopulmonary Exercise Testing (CPET) done
Have complete body composition testing done
Have muscle and fat composition testing done using a hand-held ultrasound device
Complete physical function and cognitive function assessments